Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis

Abstract Background Chronic hepatitis C (HCV) infection is a leading cause of liver cirrhosis (LC) worldwide with decompensation-related clinical sequelae. Sarcopenia currently recognized as fundamental complication LC owing to various mechanisms. This study aimed assess the role anthropometric measures sarcopenia in predicting outcome assessed by Child-Turcotte-Pugh (CTP) grade. Results A cross-sectional was carried out on 80 patients HCV-related different CTP grades. The diagnosis based 2018 definition according European Working Group Older People (EWGSOP). Muscle strength hand grip (HGS) and lower leg extension (LES). Assessment muscle mass performed measuring mid-calf circumference (MCC) mid-arm (MAMC). HGS varied significantly between grades, being highest grade C. Additionally, number diagnosed “definitive sarcopenia” using either HGS/MCC or LES/MCC Conclusions better predictor worse outcomes than LES. combination MCC LES potentially promising noninvasive prognostic biomarker disease.